The Seagulls will be trying to score a first goal since Saturday 5 March.
Graham Potter is giving a full debut to Moises Caicedo.
The Albion midfield will also be packed with Enock Mwepu, Alexis Mac Allister, Leandro Trossard and Pascal Gross.
Neal Maupay is dropped to the bench and former Arsenal striker Danny Welbeck is due to start up front.
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