Albion take on in-form Spurs at the Amex after the 3-2 setback at Selhurst Park against Crystal Palace.
Again (!) three points could secure the Seagulls’ Premier League status.
When the teams met at Wembley in December, Spurs were flattered by the 2-0 scoreline.
Since then, they have lost just twice in the league – both times to new champions Manchester City.
Seagulls skipper Bruno Saltor returns to the starting line-up at the expense of Ezequiel Schelotto who takes his place on the bench.
Spurs are without Deli Alli but Harry Kane is in the Londoners’ much-changed starting line-up.
Albion: Ryan; Bruno, Duffy, Dunk, Bong; Knockaert, Kayal, Stephens, Gross, Izquierdo; Murray.
Subs: Krul, Schelotto, Goldson, March, Locadia, Ulloa, Baldock.
Spurs: Lloris, Davies, Vertonghen, Alderweireld, Aurier; Wanyama, Sissoko, Son, Eriksen, Lucas Moura; Kane.
Subs: Vorm, Dembele, Dier, Foyth, Lamela, Llorente, Trippier.